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In recent years, we have witnessed a renewed interest in psychedelic therapy and research being called “the psychedelic renaissance.” Many people are discovering the potential benefits of psychedelic substances and master plants, and shamanism has become an increasingly sought method for healing. Dozens of clinical trials study the efficacy of psychedelic medicines such as MDMA, psilocybin, and ketamine to treat serious conditions like PTSD and treatment-resistant depression. With respect to this new era of psychedelics, those of us involved with the Holotropic paradigm have much to contribute and consider. How do psychedelics compare with or compliment Holotropic Breathwork® as tools for personal development? What is the role of Holotropic Breathwork® now that psychedelics are becoming an accessible therapeutic method? How is the future of Holotropic Breathwork® affected, now that more people can access deep experiences through psychedelics and master plants?